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Our Integrated Infrastructure

The DDU is housed within purpose-built facilities at the University of Dundee and has all the expertise required for early-stage drug discovery and development.

Translational Science

Drug Metabolism and Pharmacokinetics
  • Integrated DMPK group
  • Supports hit and lead optimisation programmes
  • Industry standard in vitro and in vivo assays
  • State-of-the-art UPLC-MS/MS

 

Hit Discovery
  • Comprehensive range of liquid handling and detector technologies, including nanolitre acoustic dispensing
  • Protein and cell-based screening
  • High-content imaging and analysis
  • Fragment-based screenings: SPR, NMR and Octet RED284
  • Industry standard data management - ActivityBase, Dotmatics
Medicinal Chemistry
  • Hit validation to lead optimisation
  • Parallel chemistry
  • Mass directed auto-prep HPLC purification
  • Structural Biology & Biophysical Techniques
  • State-of-the-art protein crystallography infrastructure
  • SPR: hit validation and determining enzyme kinetics
Bioinformatics
  • Statistics, computational science, databases, algorithms
  • Management and analysis of biological data
  • Mapping, analysing and aligning DNA and protein sequences
  • Building 3D models of protein structures
Computational Drug Design
  • Druggability assessment of molecular targets
  • Library selection
  • Virtual screening
  • Analysis of hits from screening
  • Pharmacophore searching
  • Compound design using protein structures
  • In silico ADMET optimisation