Drug Metabolism and Pharmacokinetics
- Integrated DMPK group
- Supports hit and lead optimisation programmes
- Industry standard in vitro and in vivo assays
- State-of-the-art UPLC-MS/MS
Hit Discovery
- Comprehensive range of liquid handling and detector technologies, including nanolitre acoustic dispensing
- Protein and cell-based screening
- High-content imaging and analysis
- Fragment-based screenings: SPR, NMR and Octet RED284
- Industry standard data management - ActivityBase, Dotmatics
Medicinal Chemistry
- Hit validation to lead optimisation
- Parallel chemistry
- Mass directed auto-prep HPLC purification
- Structural Biology & Biophysical Techniques
- State-of-the-art protein crystallography infrastructure
- SPR: hit validation and determining enzyme kinetics
Bioinformatics
- Statistics, computational science, databases, algorithms
- Management and analysis of biological data
- Mapping, analysing and aligning DNA and protein sequences
- Building 3D models of protein structures
Computational Drug Design
- Druggability assessment of molecular targets
- Library selection
- Virtual screening
- Analysis of hits from screening
- Pharmacophore searching
- Compound design using protein structures
- In silico ADMET optimisation