Publications | Drug Discovery Unit

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Dec 2017

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments

Publication Date:
12 Dec 2017

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Nov 2017

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

Publication Date:
10 Nov 2017

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Oct 2017

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

Publication Date:
02 Oct 2017

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Aug 2017

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethyl

Publication Date:
30 Aug 2017

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Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

Publication Date:
27 Aug 2017

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The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

Publication Date:
14 Aug 2017

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Jul 2017

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)

Publication Date:
10 Jul 2017

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Feb 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Publication Date:
27 Feb 2017

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Jan 2017

Communicating Our Science to Our Customers: Drug Discovery in Five Simple Experiments

Publication Date:
31 Jan 2017

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Nov 2016

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform

Publication Date:
07 Nov 2016

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Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

Publication Date:
03 Nov 2016

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Oct 2016

Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening

Publication Date:
24 Oct 2016

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Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

Publication Date:
05 Oct 2016

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Sep 2016

Exploring the Leishmania Hydrophilic Acylated Surface Protein B (HASPB) Export Pathway by Live Cell Imaging Methods

Publication Date:
25 Sep 2016

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Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Publication Date:
10 Sep 2016

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