Publications | Drug Discovery Unit

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Dec 2018

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.

Publication Date:
20 Dec 2018

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Nov 2018

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.

Publication Date:
12 Nov 2018

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Oct 2018

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1.

Publication Date:
15 Oct 2018

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2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease.

Publication Date:
01 Oct 2018

Publication Link

Sep 2018

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome

Publication Date:
28 Sep 2018

Publication Link
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Publication Date:
12 Sep 2018

Aug 2018

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past to Help Discover Long-Acting Oral Drugs in the Future.

Publication Date:
24 Aug 2018

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Jul 2018

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.

Publication Date:
25 Jul 2018

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Challenges and recent progress in drug discovery for tropical diseases.

Publication Date:
25 Jul 2018

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Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery.

Publication Date:
12 Jul 2018

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Jun 2018

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.

Publication Date:
26 Jun 2018

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May 2018

Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug Discovery Campaigns.

Publication Date:
07 May 2018

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Apr 2018

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and it's newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users.

Publication Date:
05 Apr 2018

Publication Link

Mar 2018

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. ACS Infectious Diseases.

Publication Date:
09 Mar 2018

Publication Link

Feb 2018

Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA.

Publication Date:
05 Feb 2018

Publication Link

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