Publications | Drug Discovery Unit

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Jul 2018

Challenges and recent progress in drug discovery for tropical diseases.

Publication Date:
25 Jul 2018

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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.

Publication Date:
25 Jul 2018

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Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery.

Publication Date:
12 Jul 2018

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Jun 2018

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.

Publication Date:
26 Jun 2018

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May 2018

Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug Discovery Campaigns.

Publication Date:
07 May 2018

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Apr 2018

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and it's newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users.

Publication Date:
05 Apr 2018

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Mar 2018

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. ACS Infectious Diseases.

Publication Date:
09 Mar 2018

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Feb 2018

Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA.

Publication Date:
05 Feb 2018

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Jan 2018

Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindaw (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl-4-hydro

Publication Date:
25 Jan 2018

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Dec 2017

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments

Publication Date:
12 Dec 2017

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Nov 2017

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

Publication Date:
10 Nov 2017

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Oct 2017

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

Publication Date:
02 Oct 2017

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Aug 2017

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethyl

Publication Date:
30 Aug 2017

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Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

Publication Date:
27 Aug 2017

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The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

Publication Date:
14 Aug 2017

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