Publications | Drug Discovery Unit

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Apr 2016

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi

Publication Date:
29 Apr 2016

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Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade

Publication Date:
15 Apr 2016

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Jan 2016

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA

Publication Date:
19 Jan 2016

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Nov 2015

A substrate mimic allows high throughput assay of the FabA protein and consequently the identification of a novel inhibitor of Pseudomonas aeruginosa FabA

Publication Date:
10 Nov 2015

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Oct 2015

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Publication Date:
05 Oct 2015

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Sep 2015

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

Publication Date:
28 Sep 2015

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Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity

Publication Date:
25 Sep 2015

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Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease.

Publication Date:
23 Sep 2015

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Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

Publication Date:
22 Sep 2015

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Jun 2015

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Publication Date:
18 Jun 2015

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Apr 2015

Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase.

Publication Date:
21 Apr 2015

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Feb 2015

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

Publication Date:
23 Feb 2015

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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

Publication Date:
01 Feb 2015

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Dec 2014

Identification of Small Molecule Inhibitors of Pre-mRNA slicing

Publication Date:
12 Dec 2014

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Nov 2014

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Publication Date:
20 Nov 2014

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