Publications | Drug Discovery Unit

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Aug 2013

Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter.

Publication Date:
09 Aug 2013

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Structure-activity relationship studies of pyrrolone antimalarial agents.

Publication Date:
05 Aug 2013

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Jul 2013

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis.

Publication Date:
15 Jul 2013

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Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay.

Publication Date:
01 Jul 2013

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Jun 2013

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules

Publication Date:
14 Jun 2013

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A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assay

Publication Date:
03 Jun 2013

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Mar 2013

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Publication Date:
27 Mar 2013

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Locating Sweet Spots for Screening Hits and Evaluating Pan-Assay Interference Filters from the Performance Analysis of Two Lead-like Libraries

Publication Date:
04 Mar 2013

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Nov 2012

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes.

Publication Date:
29 Nov 2012

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Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

Publication Date:
16 Nov 2012

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Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.

Publication Date:
08 Nov 2012

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Jul 2012

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases.

Publication Date:
01 Jul 2012

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Jun 2012

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays.

Publication Date:
25 Jun 2012

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Apr 2012

Assessment of Pseudomonas aeruginosa N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase as a potential antibacterial drug target.

Publication Date:
25 Apr 2012

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IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening.

Publication Date:
25 Apr 2012

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